Alteration of drug metabolism in Gilbert's syndrome.
نویسندگان
چکیده
منابع مشابه
Alteration of drug metabolism in Gilbert's syndrome.
The pathophysiology of Gilbert's syndrome was studied by investigating the metabolism of the drug tolbutamide, which is metabolised by the liver but does not undergo glucuronidation. Using rat liver cell supernatant, tolbutamide was shown to bind to the hepatic cytoplasmic Y protein in a manner similar to other organic anions, but not to Z protein. In 31 patients with Gilbert's syndrome the pla...
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ژورنال
عنوان ژورنال: Gut
سال: 1976
ISSN: 0017-5749
DOI: 10.1136/gut.17.8.581